We’ve been talking about thiols and disulfide bonds a lot lately and it’s been super useful for my research. I rely a lot on thiol reactions in my research since thiols stick really well to gold. Sulfur-gold reactions are semi-covalent, with a strength of about 45 kcal/mol, which is ideal since we want to attach all the components to the gold as strongly as possible. To get everything attached on the gold, we have to introduce a free thiol on to each component but make sure that the thiols don’t form disulfide bonds. So today’s lesson on pH and pKa in thiols was an especially important and really useful!
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Let me know Harini if any of these discussions helps you optimize any of your reactions and get a better yield perhaps with adjusting your pH just a bit.. Great to see you connecting your course work with your research!!!