I decided to use the ink drawing methods shown to our class by Daniela Rivera. To apply the ink I used variations on the ink dripping and blowing technique as well as using a twig and sponge. I explored how … Continue reading
This was my piece for the art portion of prions. I saw the long structures as neurons and dendrites in the brain, corrupted by the invading prions. The ink lent itself well to spreading in an organic way reminiscent of … Continue reading
In my drawing I decided to do a scientific cartoon. After several weeks of focusing on prions, it has been made quite clear that prions are proteins that can adopt two forms; normal, and misfolded. One single misfolded protein shouldn’t … Continue reading
Here is my piece for the visual art and prions assignment. I chose to represents the beta sheets of PrPSc, after the alpha helices of PrPc have been misfolded and malformed into the infectious PrPSc structure. This flip from … Continue reading
Art interpretation: Pathology in Patient, March 2014 Science interpretation: Visual representation of human brain tissue “infected” by Creutzfeldt-Jakob prion disease For the arts assignment that we did in last class, I attempted in my work to echo prion infected brain tissue. This … Continue reading
My project for this week is conceptually similar to the musical illustration I prepared for last week’s assignment. I find myself being continually fascinated by the perfect interlocking mechanisms embedded in human and animal biology, and the contrast of this … Continue reading
In my attempt to compose a prion sequence, I chose the Octapeptide Repeat Region because it is somewhat mysterious in its repetitive pattern. Compared to rest of the sequences that are appear very complex and erratic, I wanted to represent the octapeptide uniformly 4×4 which was a response to its geometric name repeating the eight amino acid sequence. Thus, I included to render this geometric function through the sound of a synthetic instrument (synthaltered keyboard) that I used to compose in Mac OSX Garagband programme. PQGGGGWGQ PHGGGWGQ PHGGGWGQ PHGGGWGQ PHGGGWGQ CDGGGGAGF CEGGGAGF CEGGGAGF CEGGGAGF CEGGGAGF The musical piece itself is very basic, but after having spent the time with revising biochemistry, and reflecting on the information from last class, the way I see the prion structure when I hear the piece is reminiscent of this learning process. I think I would like to go deeper scientifically, mathematically, and musically with the composition in the future. The slow pace of the piece reflects the association with the length of the octapeptide: in this case I wanted to make a connection to neurodegenerative symptoms. Within a given species, repeats at the amino acid level are not always perfect. In addition, it has been researched that mutations with extra repeats can cause Creutzfeldt-Jakob … Continue reading
This is my representation of prions through visual art. What I decided to do was portray the progression of abnormal prions from first entering the cell body to after a significant amount of time passes. As you can tell from … Continue reading
I wanted to create the musical effect of one infectious prion propagating slowly, as it duplicates and converts each consecutive normal protein at a time. I had some trouble using Pure Data also, and resorted to Audacity. Even with Audacity, … Continue reading
I utilized the water, brush, twig, and black ink method Professor Rivera taught us during the first portion of class. I wanted to represent the way in which microscopic pores form in tissue sections affected by prions, causing the tissue … Continue reading