One of the the aspects of prion disease that interests me most is its long incubation period. An incubation period is the time between the moment a person is infected with a pathogen and the moment a person starts displaying symptoms of disease. In the case of prion diseases, incubation periods can last three years. Incubation periods are vital to understand the epidemiological structure of disease. How can you trace the spread of disease if you do not know when the infection was contracted?
The incubation period is distinct from the contagious period, in which disease can be spread from organism to organism. As someone that works with children, I was curious about the differences between incubation periods in young and old people. It turns out that children have shorter incubation periods than adults (because their bodies are worse at fighting the illness) but that they have longer contagious periods. This reason, along with others, is why children tend to get more sick than adults.
To connect back to our class activity, I was confused about why children were getting the neurodegenerative illness. Often neurological symptoms are common in older adults who suffer from MS, Alzheimer’s, Parkinson’s, and ALS, so it was disturbing to me that kids were getting it. Certainly a strange case. I wondered about early onset Alzheimer’s, which is on the rise, for reasons that doctors do not know. This seems to highlight the importance of epidemiologists and the hard work that they have to do.
Here is a chart I found about the incubation and contagious periods of common illnesses!
http://en.wikipedia.org/wiki/Incubation_period http://www.childrensoscillo.com/features/healthy-kids/http://www.childrenshealthnetwork.org/CRS/CRS/pa_incubate_hhg.htm Incubation Disease Period (days) Contagious Period --------------------------------------------------------------- --------------------------------------------------------------- SKIN INFECTIONS Chickenpox 10 to 21 5 days before rash until all sores have crusts (5-7 days) Hand, foot, and mouth 3 to 6 Onset of mouth ulcers disease until fever is gone Impetigo (strep or staph) 2 to 5 Onset of sores until 24 hours on antibiotic Measles 8 to 12 4 days before until 5 days after rash appears Meningitis 3 to 6 Onset of symptoms and for 1 to 2 weeks Rubella (German measles) 14 to 21 7 days before until 5 days after rash appears Shingles (contagious 14 to 16 Onset of rash until for chickenpox) all sores have crusts (7 days) (Note: No need to isolate if sores can be kept covered.) --------------------------------------------------------------- RESPIRATORY INFECTIONS Bronchiolitis 4 to 6 Onset of cough until 7 days Colds 2 to 5 Onset of runny nose until fever is gone Cold sores (herpes) 2 to 12 See footnote B Coughs (viral) 2 to 5 Onset of cough until fever is gone Influenza (Seasonal) 1 to 3 Onset of symptoms until fever is gone over 24 hours Influenza (H1N1) 4 to 6 Onset of symptoms until fever is gone over 24 hours Sore throat, strep 2 to 5 Onset of sore throat until 24 hours on antibiotic Sore throat, viral 2 to 5 Onset of sore throat until fever is gone
This is really interesting! I was thinking about the incubation of prion diseases too after last class and am still wondering how the incubation period is measured. Does eating the brain matter always lead to infection? Did the scientists who used chimpanzees for testing discover the incubation period during their testing because they could control and know exactly when exposure happened?