As we have learned, prion disease is essentially PrPc that transforms into a malicious variant which has a negative effect on the nervous system and likewise, a negative effect on the memory and other cognitive functions. Per the research and imagery provided by the video from the neuropathologists of the University of Zurich and the University Hospital Zurich, it seems the surfaces where the antibodies and the prion protein are connected is not a very large surface. If I understand correctly, the thickness of the slice has a correlation with the prion protein’s characteristics; thus with a smaller amino terminal there is no possibility for toxicity.
This is all based on previous research in junction with further hypotheses. It is fascinating that these such protein reactions can be predicted given both their complexity in general and their complexity in observation. I would be interested in further understanding the thought process of scientists in the trajectory of their thinking of how to address genetic diseases. As an anthropologist, I would have focused more on the lifestyle practices that could progress the mutation and formation of the prion disease.