Funding Source: NIH R15 AREA 1R15GM151679-01 – Antimicrobial peptides are small protein molecules that kill bacteria, and they may be promising alternatives to traditional antibiotics, which can easily succumb to bacterial resistance. As part of an ongoing collaboration, members of … Continue reading Multi-Target Design and Analysis of DNA-Binding Antimicrobial Peptides
Funding Source: NIH R01GM134380 – Extracellular ATP and ADP are mediators of purinergic signaling in cell-to-cell communication in virtually every tissue. Autocrine and paracrine purinergic signaling contributes to normal cellular functions such as immune cell chemotaxis and cell volume regulation, … Continue reading Optical Tools to Study Purinergic Signaling
A distinctive feature of pancreatic cancer cells is their tolerance to nutrient- and oxygen-deprivation. Pancreatic cancer cells, including PANC-1, can survive for 48 hours in the absence of essential amino acids, glucose, and serum, whereas normal cells die within 24 … Continue reading Using Organic Synthesis and Natural Product-derived Scaffolds to Identify Novel Anticancer Agents
Funding Source: NIH R15/AREA (2R15AI079685); Previously funded by a Henry Dreyfus Teacher-Scholar Award and by Research Corporation – Bacteria that have developed antibiotic resistance pose an increasing health risk. Antimicrobial peptides are small proteins produced by a wide variety of … Continue reading Characterization and Design of Histone-Derived Antimicrobial Peptides