Maryland v. King: Another step towards a DNA age

I am not a legal expert. What follows is in no way intended to be a legal exegesis of the arguments at stake in the recently decided Maryland v King supreme court case. However, I do know something about genomics and have a strong academic interest in the public consumption and circulation of genomic data. My response to the 5-4 supreme court decision, upholding the right of police to take DNA information from individuals arrested for–but not convicted of–criminal activity, comes from this perspective.

DNA is not just a fingerprint
My initial response to the oral arguments in this case focused on what I saw as Anthony Kennedy’s misleading characterization as DNA identification as the “21st century fingerprint.” I maintain that objection now, despite this analogy situating prominently in the SCOTUS decision:

When officers make an arrest supported by probable cause to hold
for a serious offense and bring the suspect to the station to be detained in custody, taking and analyzing a cheek swab of the arrestee’s DNA is, like fingerprinting and photographing, a legitimate
police booking procedure that is reasonable under the Fourth
Amendment (emphasis added)

As I said previously, DNA is a wonderful unique identifier, but it contains a lot more information than simply who you are right now. Much more information, I would argue, than is embedded within a fingerprint or photograph. DNA says something not just about who you are, but also who your relatives are, and potentially about who you or your relatives might become in the future. It is this added informational property of DNA that underscores my objection to both the analogy and the SCOTUS decision.

An important part of the majority’s rationale is the fact that the Maryland law only allows for the genotyping of CODIS (Combined DNA Index System) markers, the set of 13 short-tandem repeat loci (STRs) used by federal law enforcement for DNA identification. The majority opinion cites a 2012 article by Katsanis & Wagner, which examined what you can learn, aside from identity, from the 13 CODIS markers. They conclude that at this time, there is little else that can be gleamed from these STR sites, but note that this conclusion could change in the future. Both Katsanis and Wagner appeared on a Huffpost live discussion this morning to talk about the case, a conversation I highly recommend watching (here is the link).

The heart of the majority decision rests on the interpretation that DNA can be used as an identifying element in a normal booking procedure, despite acknowledging that DNA, because of the time and cost associated with genotyping, cannot actually do this at the present. Rather, the advantage of DNA is in criminal investigation related to past crimes. Justice Kennedy’s rationale rests of subsuming one’s past crimes into the notion of identity.

The only difference between
DNA analysis and fingerprint databases is the unparalleled accuracy
DNA provides. DNA is another metric of identification used to connect the arrestee with his or her public persona, as reflected in records of his or her actions that are available to the police (p. 3)

It may not be as fast as fingerprinting (p. 3)

To my legally naive self, this seems dubious and seems instead to represent a warrant-less search (i.e. an investigation of unrelated crimes under the auspices of an arrest). In thinking about this from an anthropological perspective it is worth pointing out that arrests by law enforcement are social actions that reflect the biased distribution of power within our society. As an example, there was considerable reporting this week about huge disparities in arrests for marijuana despite similar rates of usage between white and black Americans (for a recap, see here). As citizens, we have some capacity to prevent wrongful conviction, but little capacity to prevent wrongful arrest. This decision effectively turns arrests into an investigative tool through DNA identification.

Incentivizing DNA utilization
Expanding on the implications of this decision a little more, this is yet another step in the movement towards incentivizing the use and development of genetic technologies. The effectiveness of DNA in resolving cold-case files means this could actually have a much greater immediate impact than the genetic revolution of “personalized medicine,” but at the cost of much individual genetic privacy. There is a great post by Michelle Meyer at The Faculty Lounge that touches on some of these issues.

Readers with either response to King — horror or nonchalance — should consider the merits of a universal DNA database — one that contains 13 identifying loci from each of us, with a prohibition on further analysis of those loci (which are very unlikely to reveal any significant information beyond identity, in any event), and penalties for violating that prohibition. Collecting DNA from arrestees to solve unrelated crimes not only constitutes a search without individualized suspicion, it also constitutes a search of individuals (an arrestee’s relatives) whose legal relationship to the state has not, unlike the arrestee, resulted in a reduced expectation of privacy, and additionally subjects them to more traditional investigation and surveillance by the state. Moreover, it disproportionately subjects some ethnic/racial minorities and other groups to such indirect surveillance. If we’re going to include in “offender” databases individuals whom we have absolutely no reason to suspect of having committed any offense, then it seems only fair to equally distribute whatever privacy burden that entails on everyone. A universal database would also avoid exacerbating the problem of a criminal justice system already viewed as discriminatory (and hence illegitimate) towards certain groups in our society. And what better way to promote reasonable uses of the database and the adoption of meaningful penalties for its misuse than to include everyone in it — including lawmakers and other powerful individuals?

The Maryland law is set up so as to expunge DNA profiles if their is a failure to convict, but this aspect of the statue varies across jurisdictions. Indeed, in most states that collect DNA profile information, the burden to initiate expunging of data from databases falls on the individual. So another implication of this decision is to encourage the continued development of large, public DNA databases. This can be viewed in multiple ways. I am a big open access fan, and large public databases are wonderful tools for encouraging openness and developing high quality research. However, is the appropriate executer of such a database federal, state and local law enforcement?

It should also be pointed out that DNA identification, while dramatically cheaper than it was even a few years ago, comes at a greater monetary cost than current identification practices. A big winner in this decision is the genomics industry. It is less clear whether your average on the street law enforcement officer wins. It is pretty clear that anyone with concerns about individual genetic privacy is likely to be a loser in this case.

******

1. Katsanis, Sara H., and Jennifer K. Wagner. “Characterization of the Standard and Recommended CODIS Markers*.” Journal of forensic sciences 58.s1 (2013): S169-S172. DOI:10.1111/j.1556-4029.2012.02253.x

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Breaking: Supreme court rules against DNA privacy

With June here, the Supreme Court is beginning to release their opinions on this term’s cases. One of the first announced this morning is the case of Maryland v. King (I wrote about the case earlier). At stake is whether or not police have the authority to take DNA for individuals arrested, but not yet convicted, of a crime. The Supreme Court, with Anthony Kennedy writing in the majority, ruled 5-4 in favor of granting police this authority, calling it “a legitimate police booking procedure.”

I will have more on this later as my body returns to East Coast time. In the meantime, follow Scotus Blog’s coverage here.

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One last shot from Almaty…

Fieldwork is done for the time being, the only tasks that remain are gift shopping, packing and departing.

Almaty

Prof. Zhaken Taimagambetov (Al-Farabi Kazakhstan National University) was a wonderful host during my stay.

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Preview video for Anth 207x

The course “trailer” for Anth 207x (Introduction to Human Evolution) has been released. You can check it out at EdX or directly on YouTube. It was fun to film and has me looking forward to producing much of the rest of the class when I return to Wellesley in a few days.

screencap

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Back from the Charyn Canyon

Charyn

Made it back into Almaty after two days in the Charyn Canyon region of Kazakhstan. We were able to re-identify a few Paleolithic scatters first identified by Russian archaeologists in the 1980s. I found a fossil bovid tooth, but sadly, nothing else.

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What I am attempting to read today…

…before returning to the field.

Properties and rates of germline mutations in humans (C.D. Campbell, E.E. Eichler)
Trends in Genetics, 17 May 2013, 10.1016/j.tig.2013.04.005

ABSTRACT: All genetic variation arises via new mutations; therefore, determining the rate and biases for different classes of mutation is essential for understanding the genetics of human disease and evolution. Decades of mutation rate analyses have focused on a relatively small number of loci because of technical limitations. However, advances in sequencing technology have allowed for empirical assessments of genome-wide rates of mutation. Recent studies have shown that 76% of new mutations originate in the paternal lineage and provide unequivocal evidence for an increase in mutation with paternal age. Although most analyses have focused on single nucleotide variants (SNVs), studies have begun to provide insight into the mutation rate for other classes of variation, including copy number variants (CNVs), microsatellites, and mobile element insertions (MEIs). Here, we review the genome-wide analyses for the mutation rate of several types of variants and suggest areas for future research.

Establishing the baseline mutation rate throughout our evolutionary past is hugely important. The mutation rate establishes the “clock” that allows researchers to estimate the dates of key evolutionary events based on genetic data. Prior to readily available genomic data, the rate of mutation was indirectly estimated by looking at divergence data between lineages and fossil-based estimates of divergence time. Since about 2008, an increasing number of studies have attempted to directly measure this value by looking at genomic data in pedigrees (basically, how many de novo mutations arise between parents and offspring?). Since these studies have begun to emerge, a number of different estimates for the human baseline mutation rate have emerged, but most of them share the property that they are considerably slower than older, long-term observations of mutation rates based on fossil calibration.

Of course, mutation rates are not a single, monolithic figure. Different classes of mutations appear to have different rates. Additionally, mothers and fathers do not appear to contribute equally to de novo mutations, with father’s providing the majority of new mutations (an observation predicted by evolutionary theory). The above paper provides a review of a lot of this recent research, with additional commentary on its evolutionary significance.

The piece that remains to be fully explored is how, theoretically and practically, short-term rate estimates connect with long-term rate estimates. The problem for mutation is analogous to the problem for selection (short-term selection rates invariably exceed long-term rates of selection by a large margin). The observation that current short term rates of mutation are considerably slower than estimates of long-term rates is not a rejection of the latter…rather it is simply a different observation. Increasingly, it appears to be an observation that is solid in its groundings. Now the challenge is to figure out how to directly test why the two rates are different, or alternatively, how short-term rates translate to long-term rates.

Barium distributions in teeth reveal early-life dietary transitions in primates (C. Austin, T.M. Smith, A. Bradman, et al.)
Nature (2013) doi:10.1038/nature12169

ABSTRACT: Early-life dietary transitions reflect fundamental aspects of primate evolution and are important determinants of health in contemporary human populations1, 2. Weaning is critical to developmental and reproductive rates; early weaning can have detrimental health effects but enables shorter inter-birth intervals, which influences population growth3. Uncovering early-life dietary history in fossils is hampered by the absence of prospectively validated biomarkers that are not modified during fossilization4. Here we show that large dietary shifts in early life manifest as compositional variations in dental tissues. Teeth from human children and captive macaques, with prospectively recorded diet histories, demonstrate that barium (Ba) distributions accurately reflect dietary transitions from the introduction of mother’s milk through the weaning process. We also document dietary transitions in a Middle Palaeolithic juvenile Neanderthal, which shows a pattern of exclusive breastfeeding for seven months, followed by seven months of supplementation. After this point, Ba levels in enamel returned to baseline prenatal levels, indicating an abrupt cessation of breastfeeding at 1.2 years of age. Integration of Ba spatial distributions and histological mapping of tooth formation enables novel studies of the evolution of human life history, dietary ontogeny in wild primates, and human health investigations through accurate reconstructions of breastfeeding history.

This looks like a cool study. Basically, the authors have found a chemical signal, observable in dental enamel, that distinguishes changes in infant diet. Specifically, they are trying to determine the age at which children move off a breastmilk-exclusive diet and the age at when they move off breastmilk entirely. Evolutionarily, these are important transitions, as they represent important transitions in childhood diet, maternal energetics, and the evolutionary relationship between mother and child. There are theoretical expectations, based on living humans and non-human primates, about when these events should occur, and previous fossil based studies, but the latter have been built upon assumptions not tested in the field. This appears to be a novel and more direct way to address these issues. I also like that the authors do not take their one fossil observation (a Neandertal from Belgium) and run wild with it.

Katie Hinde, one of the co-authors of this study, has more on her blog.

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The hardest part about being in the field

There are many many wonderful things about doing paleoanthropological fieldwork. I spent most of the past week doing survey work in a beautiful, though vast, section of South-Central Kazakhstan. I can certainly think of worse things to do then spend the day walking across kilometeres of beautiful landscape, finding everything from later Paleolithic stone tools, a few fossils, Holocene ceramics and a Bronze Age pestle (plus snakes, scorpions, turtles, and fantastic birds!).

In addition to all of the above, the highlight of the week might actually have come on our final day, when we were invited to the local Kurdish village to participate, as honored guests, at the final day of the school year handing out end of the year certificates.

Graduation

Why is there a Kurdish village in the middle of South Central Kazakhstan? Because in the middle of the winter in 1937 Stalin decided to relocate millions of ethnic minorities from various parts of the Soviet Union (in this case, parts of the Southern Caucasus) to the vast Western expanse of the Soviet Union. The village we were camped near (the only settlement for about 25km in any direction) represent the descendants of that forced migration, 75+ years later. And it turns out they have a wonderful school these days (As an aside, have any geneticists explored the genetic effects of Stalin’s forced migrations? I would love to see the studies if they are out there.).

But while there are many great and unexpected parts to field work, for me the hardest part of the experience is always the separation from my family. When I was a graduate student, the prospect of completely removing myself from e-mail was heavenly. These days, with a family (including a new born) at home on the opposite side of the globe, the prospect is harrowing. The challenge was made real for me this week when, after a week in the field, I managed to get just enough internet connection to find this e-mail:

Where are u now? We are at hospital w Flora for shoulder fracture. Tough.

Flora is my 11-year old daughter, injured, I later discovered, when she was knocked down on the lacrosse field. She will be fine, but I would certainly like to have been by her side this past week.

Fieldwork is a sacrifice, but it is a valuable one and one that I am happy to partake in. While discovery is at the heart of our discipline, I do not think everyone needs to be actively engaged in fieldwork to be contributing to the advancement of the discipline. The amount of unanswered questions within our field that could be addressed with lab work and/or existing data is vast (and theory is extremely important!). But fieldwork is the fundamental source of new observational data in our field. Less appreciated, but perhaps more important, fieldwork is a major way that connections within our field are made. In my case this week, I was part of an international team focused on researchers from Colorado State (Mica Glantz, Jason LaBelle and a couple of their grad students) and Kazakhstan (led by Zhaken Taimagambetov), but also including American, Belgian, Italian, Romanian and Australian colleagues. The opportunity to contribute to capacity-building activities in less advantaged countries is, in my opinion, the most valuable aspect of such work. But fieldwork is a sacrifice.

UPDATE: Zach Cofran (Nazarbayev U.) has a more thorough update on our activities…

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Greetings from Kazakhstan!

I am very briefly back in Almaty after a successful week at the Paleolithic site of Valikhanova, in South Central Kazakhstan.

Sunset

While I was away, the announcement of my Fall course, Anthro 207x – Introduction to Human Evolution, done in partnership with EdX, went live. If you have ever wondered what I do, this is your chance to find out.

I will try to provide more updates on my current fieldwork, the course, and other related thoughts when my internet connection allows…

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Anthropology 207x – Making it easier to ask better questions

In my post yesterday, I pointed out that one of my goals in Anthropology 207x is to disseminate a lot of information about human evolution. In addition to disseminating this information, my plan is to also provide an introduction to many of the methods used in paleoanthropology to generate knowledge. Anthropology 207x will include virtual lab module each week that are intended to provide students with basic introductions into not just what we think we know about human evolutionary history, but how and why we think these things.

In all of my introductory teaching, one of my main goals is to teach students how to ask good questions. The same will hold true for 207x.

CastScans

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Anthropology 207x – My goals

One of the first things I want to convey about Anthropology 207x (Introduction to Human Evolution) are my goals in putting together the course.

Dissemination
My largest goal for this course is make available valuable teaching content related to human evolution. Evolution, particularly when the subject is humans, remains controversial. Part of this has to do with poor educational resources related to teaching the subject.

This course will be open. This course will be free. This course will provide students with a LOT of information (pictures, videos, maps, discussion, labs, data) related to human evolution and the fossil, archaeological, and genetic records.

Pedagogical Improvement
In addition to teaching Anthropology 207x online this Fall, I will be teaching the same course on campus. Or…kind of the same course. The experience for my on-campus Wellesley students, while they will have access to everything in the Anthropology 207x course, will be quite different. I will use some of the online content in my on-campus course to free up time in class for more discussion. Given the introductory nature of the course, when I teach it, I generally have to do a large amount of lecturing. By flipping much of that lecture, in addition to lab modules, online, we will have more time in class to get into some of the nitty-gritty details of the topic.

I suspect many of these issues will also come up in the Anthropology 207x course, particularly in the discussion forums, though the experience will likely be quite different given the different format. One of the things we will play around with this Fall is using the discussions that take place in my on-campus course to seed discussion topics in the online forums of 207x.

I also think that the process of preparing this course (which, I can assure you, is a considerable amount of work) will, by itself, make me a better instructor for the course, whatever the environment.

Generate Interest in Evolutionary Studies
One of the most enjoyable things about working in the arena of human evolution is that people are generally quite interested in the topic. I have been at numerous unrelated events and dinners where, when my line of work came up in conversation, a nearly endless series of questions began to come my way. I am hopeful that students who take my course, rather than seeing it as an answer to all their questions (though certainly we will try to provide some of those), will instead find themselves wanting to ask and seek out the answers to more evolutionary questions.

One of the fears around the rise of MOOCs is that they will actively undercut the fields, institutions and researchers they represent. I think there are legitimate reasons to share these fears, and I have tried to structure my course in response to them. Anthropology 207x is not offered for credit. Students who successfully complete the course will be offered a certificate of completion, but not credit equivalent to an on-campus course. My hope is that students at other institutions (or, indeed, Wellesley) who experience 207x will be inclined to seek out classes and people related to the topic at their own institutions. I don’t want my course to replace the 200+ other Intro Human Evolution courses that will be taught around the country this Fall, but I do want to increase the pool of people interested in taking those courses.

At this stage, I see MOOCs as a potentially valuable and complementary educational mechanism, but not a replacement one. There is simply no way to create my on-campus seminar course, with 20 students and one me, into an online course with 20,000 students and one me, and expect it to be the same thing. But that is fine, it does not have to be the same thing to be valuable.

Take Advantage of the Properties of a Truly Massive Classroom
My final goal for 207x is to structure the course in such a way as to truly take advantage of the (potentially) massive scale of the course. Teaching about human evolution involves a major focus on teaching about human (and non-human primate) variation. What kind of variation do we see in living humans today? How do we use that picture of variation to test hypotheses about the past? In a classroom of 20 students, even at a place with a fairly diverse student body, the amount of biological (and cultural) variation on display within the class itself is limited. Expanded by a factor of 1000, however, that potential becomes vastly greater.

I will be creating a lot of opportunities in 207x for students to submit basic data about themselves as a way of generating snapshots of what patterns of biological variation look like in a large sample of global humans in a single, virtual, classroom.

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